10/31/2022 0 Comments Reactivity effects![]() ![]() ![]() Accumulating epidemiological and experimental data suggest that sex hormones may be important physiological modulators in the lung, and the role of estrogens in asthma has received considerable attention in this regard. Females typically are more susceptible and/or develop more severe asthma, chronic obstructive pulmonary disease, lung cancer, and other lung conditions. Sex differences exist in the risk, incidence, and pathogenesis of various lung diseases in humans. Epidemiological studies of both incidence and prevalence have reported a male predominance of asthma before puberty and a female predominance after puberty. The incidence, severity, and prognosis of asthma can be affected by several factors, including the patient’s age and sex. However, whether these findings are of clinical significance in terms of the management of asthma or asthma worsening during the menstrual cycle needs further investigation.Īsthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. Our results also suggest a link between PMA and testosterone levels. Reactivity effects Pc#In conclusion, our data show that PC 20FEV 1.0 was decreased in the follicular phase of the menstrual cycle in about 30% of women and was associated with lower cAMP levels in sputum samples, which may contribute to bronchoconstriction. We excluded the possibility that testosterone directly inhibits phosphodiesterase (PDE) activity as incubating PDE with testosterone in vitro did not reduce PDE catalytic activity. Moreover, marked increases in sputum testosterone levels (mean = 2.6-fold increase) together with significant increases in sputum cAMP concentrations (mean = 3.6-fold increases) were observed during the luteal phase of asthmatic patients, suggesting that testosterone contributes to the pathophysiology of PMA. Our study showed that about 30% of the asthmatic women had decreased PC 20FEV 1.0 in the follicular phase of menstrual cycle with a significant correlation between PC 20FEV 1.0 and serum testosterone levels. We also measured plasma hormone levels and levels of cyclic adenosine monophosphate (cAMP a mediator of bronchial smooth muscle contraction) and testosterone in induced sputum samples. Methodsįor this purpose, 36 pre-menopausal women were enrolled and underwent testing for resting pulmonary function, measurement of the diffusing capacity of the lung for carbon monoxide (DLCO), and airway responsiveness to methacholine in the follicular and luteal phases of their menstrual cycles. ![]() The goal of this study was to study the effect of the luteal and follicular phases of the menstrual cycle on bronchial reactivity (BR) in a group of asthmatic women. during pregnancy and menstrual cycles (perimenstrual asthma: PMA)". Many asthmatic women complain of symptom exacerbations in particular periods, i.e. ![]()
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